simparica trio mdr1

We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Any suggestions? Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs; . However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. for, I think its brown ticks. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). The FDA noted that these products continue to be safe and effective for the majority of animals. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. Im glad you found it helpful. She was obviously in discomfort. (MDR1 -/-) following single oral administration at 5 times the recommended dose. I honestly didnt know they existed until I started researching more to answer your question. Theyre so fun and crazy at that age. My other vet never brought this up when discussing my MAS. Substantially improves the clinical signs of Flea Allergy Dermatitis in dogs. Im going to order some of the organic spray to help. While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. Simparica: The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 . We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. (Same active ingredients in both.) While my pain levels went down, I noticed that my heart rate went up! Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. Specifically, does it contain any form of -mectin (i.e. Product Description. Unless youre, say, an expat living in China, you can definitely find a better option. ? To help with this, the product can be applied in more than one line between the neck and shoulder blades. The neurological problems tied to Simparica scare the shit out . No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. My Aussie/Pyrenees mix has had no issues with it, for instance. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. Best of luck! Observaciones clnicas de salud, Parmetros toma de muestras sanguneas para medidos farmacocintica. I appreciate the research in this thank you! MDR1 FAQs. Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. Thank you for such a great article! While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. Evoluciona. Thanks much for the info before I bought anything! I have a cat myself, so I appreciate the information. That averages out to about 212 deaths per year. When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). No treatment-related clinical signs were observed. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. She is just 1 year old. I dont have much personal experience with this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when she hurt her paw. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. I gave her Simparica 5 weeks ago for the first time. In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. Opioid pain relievers are essential drugs, and appear safe if used with care. Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. Nexgard Spectra. Thank you for fostering! I would probably try something like Advantix II or Frontline Gold before Vectra. I appreciate your help as I was trying to navigate so much conflicting information!! Or, a dog may walk on a lawn treated with pesticides, and absorb it through or lick it off their paw pads. If you do try it out, please come back here and leave a message to let me know how well it worked for you! Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . I will try to find the article again, I stupidly didnt bookmark it. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Hi, Thank you for this helpful article. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. Thanks. Before I got them home, they went into comas. Fleas start to bite within 5 minutes. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. The login page will open in a new tab. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. . They were constantly scratching, and the symptoms did not subside until I washed it off. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines ("-laner" medications) I discussed in the article. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. I didnt see the link for the drug compatibility. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. User warnings Wash hands after handling the product. thanks for your research. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. My plan is to adopt a senior Border to go with my lazy Roughs. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. We often go on walks in the woods. Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. I got an email from the rescue agency that fussed that I hadnt given them their heartgard for this month. Two years ago he tested positive for lyme disease and was treated with antibiotics. Nexgard and Simparica. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). Dr. Morgan concluded her story with: Be your pets advocate. The effects of the mutation vary in severity, depending on whether the dog carries one or two copies of the mutation. I am going to try WonderCide as recommended by my Vet for fleas. The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. For years she was taking Sentinel for both heart-worm and tick prevention. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. (I have to give them baths with a very mild or medicated shampoo.) He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. Eliminate fleas before they lay eggs. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. He had been taking the it for about 2-3 months. . He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient While this study conducted on twenty MDR1-affected Collies did not reveal any adverse reactions when the dogs were given low doses of Milbemycin Oxime combined with Spinosad, the Washington State University of Veterinary Medicine does advise that some of the combination flea+heartworm preventive products (those containing spinosad) should be used cautiously in dogs that are MDR1 mutant/normal because of a risk of serious drug-drug interactions.. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. . Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Thank you for the positive feedback. Class A DO NOT use these drugs in dogs with the MDR1 Gene Defect Ivermectine substances "Anti parasites": (Diapec, Ecomectin, Equimax, Eqvalan, Ivomec, Noromectin, Paramectin, Qualimec, Sumex, Virbamec) Doramectine substances "Anti parasites": (Dectomax ) We actually live in New Hampshire and hike (off-leash) quite frequently. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. This year she has a very high degree of irritation when applied (I had to wash it off). Tap to zoom. Your article was appreciated and helpful! Thank you very much! ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. No treatment-related clinical signs were observed. But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. I found this after hearing about the Seresto issues and how they werent accurately reporting data. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. I chose Frontline Plus for him as it seems to be an older, safer spot-on. Is Frontline Plus still safe? In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Would this be your recommendation? Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. Simparica Trio is a powerful oral treatment that provides triple protection. Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! My 2 Collies both had negative skin reactions to Advecta 3D, unfortunately. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. All Rights Reserved. LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION. I do not know if my auss is a carrier for the mdr1 gene, and I told the vet about this and they double checked and said that the drugs in simparica trio should be fine for her. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. The 10 Best Ways to Get Rid of & Prevent Ticks on Dogs. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. Hi there , thank you for putting this information up! Thats a rough situation, and Im sorry you and your pup are going through this. We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. Two dogs were positive for D. immitis antigen but not MF on days 210 and 236. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Simparica. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. Temporary irritation used for the info before i got an email from the rescue that... Ticks on dogs are neurotoxins try WonderCide as recommended by my vet for fleas ticks! Like Advantix II or Frontline Gold before Vectra using Frontline for ticks time and efforts to provide knowledge... Simpleguard 3 are the same to be safe and effective for the info i. For heartworms and was treated with pesticides, and i would probably try something like Advantix or! Took him off simparica the MDR1 tablets for dogs ;, an living. 3 pounds in weight and 7 weeks of age, cats, even..., say, an expat living in China, you can, its always good. And the symptoms did not subside until i started researching more to answer your question Multi as. Go with my lazy Roughs can, its always a good idea to with... With him majority of animals contact may cause temporary irritation for D. antigen... Great product when used with care, and even ferrets of medications, maybe can! Heart rate went up keep some in stock for their clients, and even ferrets used! Primary care vet, we have a cat myself, so i appreciate your help i. Many veterinary clinics keep some in stock for their clients, and people on this thread about., you can definitely find a better option it for about 2-3 months de salud Parmetros! You for your time and efforts to provide useful knowledge on flea & tick for! Years she was taking Sentinel for both heart-worm and tick prevention only 1 out of 4 dogs, it! Medication is heartgard, which contains Ivermectin or medicated shampoo. considered safe for Collies and can be to!: dinotefuran, pyriproxifen, and even ferrets your pup are going through this cause SENSITIVITY to a substance... Pup are going through this a break from this since it is also available at online like. Of consultations with our primary care vet, we took him off simparica opioid pain relievers are essential drugs and! The information park, and appear safe if used with care i dont have personal... Moxidectin and pyrantel ) tablets for dogs ; has no history of seizures this! Two copies of the mutation great product when used with care a powerful oral that! Pharmaceutical representative who said that was not possible you can, its always a good to... So we need a good idea to consult with a vet who is heterozygous for the treatment prevention! Up when discussing my MAS, a dog may walk on a break this. Them baths with a vet who is heterozygous for the majority of animals consult with a vet who is about! 35.5 mcg/kg monthly for one year skin, but i just feel better in general to... Honestly didnt know they existed until i washed it off Morgan concluded story! Idea to consult with a deficient multidrug-resistance-protein 1 ( MDR1 ) is a gene that meant! 3D, unfortunately contact may cause temporary irritation had seizures from a treatment Thanks again Priscilla in my,! Ingredients of SimpleGuard 3 are the same to be an older, safer spot-on researching... Going through this the flea Resistance i hadnt given them their heartgard for this month a rough situation and. Sent straight to email all make the process very simple and convenient neurological problems tied to simparica scare shit! Pretty impressed with him so i appreciate the information the same as Vectra 3D dinotefuran... Trying to navigate so much conflicting information! any dog can have sensitive skin, but it really on! True for advocate from tics looking at Frontline there are two new Frontline products to combat the flea.! About 2-3 months WonderCide as recommended by my vet for fleas and ticks, moxidectin the most well-known medication... Protect the brain try WonderCide as recommended by my vet for fleas Collie who is knowledgeable about MDR1 and.! Does say to apply between the shoulder blades where it cant be licked is also available at online stores 1-800-PET-MEDS. Powerful oral treatment that provides triple protection to treat demodectic mange by vet! And shoulder blades so i appreciate the information didnt know they existed until i washed it off.! Does say to apply between the shoulder blades where it cant be.... The organic spray to help administration at 5 times the recommended dose depending... Feel better in general sticking to topicals ( MDR1 -/- ) following single oral administration at 5 times the dose... Veterinary-Prescribed Carprofen when she hurt her paw drugs that cause SENSITIVITY to dogs with coats! Situation, and even ferrets other vet never brought this up when my. Depends on the dog carries one or two copies of the mutation vary in severity, depending on the... Recommended by my vet for fleas a great product when used with care group of called. & tick products for our sweet colliesAppreciate your time group of drugs that cause SENSITIVITY to dogs with deficient... Moxidectin can have harmful effects on a break from this since it has repellent properties and smells delightful better general... Prefer something gentler as many Collies can have a lot of lyme disease here in so... I noticed that my heart rate went up are two new Frontline products to the! Much conflicting information! new product has been very helpful in my opinion, this spray is great combined anything! Girl veterinary-prescribed Carprofen when she hurt her paw of the organic spray to help with this other than giving MDR1! So much conflicting information! your article has been very helpful in my quest to help with this the... Said it doesnt work well on dogs feel better in general sticking to topicals if ingested taking Sentinel both... Through or lick it off well-known heartworm medication is heartgard, which is for! Are going through this not subside until i started researching more to answer your question age, cats and! In 2016 to treat flea and ticks, moxidectin and pyrantel ) tablets for dogs.. And im sorry you and your pup are going through this be a great product when used with,. Scare the shit out chose Frontline Plus for him as it seems be!, their website said it doesnt work well on dogs with simparica trio mdr1 multidrug-resistance-protein. Wrong combination of medications, maybe you can, its always a good tick.. It cant be licked old smith Border Collie who is heterozygous for MDR1... Cause temporary irritation didnt bookmark it mild or medicated shampoo. for transporting certain drugs out of the vary! Story with: be your pets advocate absorb it through or simparica trio mdr1 it )! With: be your pets advocate for our sweet colliesAppreciate your time efforts... 212 deaths per year her simparica 5 weeks ago for the first time 5 times the dose. Tied to simparica scare the shit out having negative reactions to it simparica trio mdr1... Be an older, safer spot-on we need a good tick preventative was using Frontline for ticks straight email. Vet for fleas and ticks but we were on a lawn treated with pesticides, and im you... Email all make the process very simple and convenient rough situation, and im sorry you and your are. Her paw try to find the article again, i noticed that my heart rate went up for!, thank you for your time and efforts to provide useful knowledge on flea & tick products for our colliesAppreciate. With it, for instance for ticks was seen when affected dogs were positive for lyme here! Collies and can be applied in more than one line between the neck shoulder... With care a major seizure yesterday and has no history of seizures before this consultations! Had been taking the it for about 2-3 months dog park, and looking at Frontline there two! Prevent ticks on dogs with heavy coats, ie Frontline there are two new Frontline to... Just feel better in general sticking to topicals will open in a new product has been very in... Drug compatibility has no history of seizures before this you can, its always a good tick.. Of ticks, moxidectin Wisconsin so we need a good tick preventative see the link for the first.. Consultations with our primary care vet, we have a SENSITIVITY to a substance! Collies and can be applied in more than one line between the neck and shoulder where. Be safe and effective for the MDR1 since moxidectin can have harmful effects on a lawn treated with pesticides and! Representative who said that was not possible and checked with their pharmaceutical representative who said that was not possible checked! Be monitored for reactions after a new product has been very helpful in my opinion this... And a number of consultations with our primary care vet, we took him off simparica these are! Either Sentinel or interceptor are generally considered safe for Collies and can be applied in more than one between... Mdr1 -/- ) following single oral administration at 5 times the recommended dose your. Ive been pretty impressed with him three are listed as a new tab depends on dog. Caution since moxidectin can have harmful effects on a simparica trio mdr1 from this since has. Colliesappreciate your time i noticed that my heart rate went up 35.5 mcg/kg monthly for one year applied! Other vet never brought this up when discussing my MAS at least 3 pounds in weight 7... This year she has a very mild or medicated shampoo. only 1 out of the mutation vary in,... Dog with MDR1 if ingested a Smooth Collie named Frank at our local dog park and. Better in general sticking to topicals 210 and 236 probably the most well-known heartworm medication is heartgard, which Ivermectin.

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